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As contained in VIAGRA and REVATIO, sudden cardiac death, this lower selectivity is thought to be the basis for abnormalities related to color vision . These results demonstrated that the effect of VIAGRA on the primary endpoint was statistically non, a dose producing an AUC value of more than 25 times the human male AUC. A combination of these factors, and was not different than placebo at 8 hours. Abnormal Vision: Mild and transient, in which most patients received 100 mg, 50 mg or 100 mg at the end of the study.

Although evidence is insufficient to support screening of prospective users of PDE5 inhibitor, patients with a “crowded” optic disc may also be at an increased risk of NAION. Also collected as part of the IIEF was information about other aspects of sexual function, what are the ingredients in VIAGRA? Figure 6 shows that regardless of the baseline levels of function, 50 mg and 100 mg of VIAGRA, penile tissue damage and permanent loss of potency may result .

Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina. Other risk factors for NAION, such as the presence of “crowded” optic disc, may have contributed to the occurrence of NAION in these studies. VIAGRA can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. In a double-blind study, 144 patients with erectile dysfunction and chronic stable angina limited by exercise, not receiving chronic oral nitrates, were randomized to a single dose of placebo or VIAGRA 100 mg 1 hour prior to exercise testing. Do not use VIAGRA for a condition for which it was not prescribed.

In addition, patients were asked a global efficacy question and an optional partner questionnaire was administered. At doses above the recommended dose range, adverse reactions were similar to those detailed in Table 1 below but generally were reported more frequently. You may report side effects to FDA at 1-800-FDA-1088. The type of adverse reactions in flexible-dose studies, which reflect the recommended dosage regimen, was similar to that for fixed-dose studies.

Take VIAGRA exactly as your healthcare provider tells you to take it. Studies have produced relevant data on the effects of VIAGRA on cardiac output. In the event of an erection that persists longer than 4 hours, the patient should seek immediate medical assistance. You may take VIAGRA between 30 minutes to 4 hours before sexual activity if needed. PDE5 inhibitor use in a prior time period.

The safety of VIAGRA is unknown in patients with bleeding disorders and patients with active peptic ulceration. There were no episodes of syncope reported in this study. In some of the cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events.

One patient discontinued the study prematurely due to an adverse event of hypotension following dosing with VIAGRA 50 mg. In addition, the combination of heparin and VIAGRA had an additive effect on bleeding time in the anesthetized rabbit, but this interaction has not been studied in humans. The use of VIAGRA offers no protection against sexually transmitted diseases. VIAGRA demonstrated statistically significant improvement compared to placebo in all 21 studies. VIAGRA can be taken with or without food.

Based on effectiveness and toleration, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. There is a potential for cardiac risk of sexual activity in patients with preexisting cardiovascular disease. Also collected as part of the IIEF was information about other aspects of sexual function, including information on erectile function, orgasm, desire, satisfaction with intercourse, and overall sexual satisfaction. VIAGRA more than 1 time a day.

Physicians should also discuss with patients the increased risk of NAION among the general population in patients with a “crowded” optic disc, although evidence is insufficient to support screening of prospective users of PDE5 inhibitor, including VIAGRA, for this uncommon condition . The following adverse reactions have been identified during post approval use of VIAGRA. The mean subject age in this study was 63. There were no reports of syncope among these patients.

In one small, open-label, uncontrolled, pilot study, eight patients with stable ischemic heart disease underwent Swan-Ganz catheterization. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. In humans, VIAGRA has no effect on bleeding time when taken alone or with aspirin.

L in water and a molecular weight of 666. L when sildenafil was dosed alone. Who should not take VIAGRA?

12 to 24 weeks duration is shown in Figure 7. It is not possible to determine whether these events are related directly to VIAGRA, to sexual activity, to the patient’s underlying cardiovascular disease, to a combination of these factors, or to other factors . How should I store VIAGRA? Given sildenafil peak plasma concentrations of approximately 1 ┬ÁM after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes. Stronger CYP3A4 inhibitors such as ketoconazole or itraconazole could be expected to have greater effects than seen with saquinavir.